Research
Hormonal
Testosterone undecanoate addition led to significant lean body mass recovery compared to tirzepatide monotherapy (66.1±3.1 kg vs. 63.4±3.0 kg, P<0.01).
Adding testosterone therapy may help preserve or enhance muscle mass in patients struggling with weight loss.
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Notably, while group A experienced progressive LBM loss, group B achieved significant LBM recovery (66.1±3.1 kg vs. 63.4±3.0 kg in group A, P<0.01).
Why this rating
The study design involves a controlled comparison between two treatment groups.
Source
Effects of testosterone undecanoate as add-on therapy in obese hypogonadal men that are late responders to tirzepatide: a pilot study
Giuseppe Seminara et al. · Minerva Endocrinology · 2026
DOI 10.23736/s2724-6507.26.04541-0
other · n=10
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Adding testosterone undecanoate to tirzepatide in late responders resulted in significantly greater body weight and fat mass reduction compared to tirzepatide monotherapy (P<0.05).Strong
- The addition of testosterone undecanoate improved insulin sensitivity and sexual health compared to tirzepatide monotherapy.Strong
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