Research
Hormonal
Testosterone undecanoate addition led to significant lean body mass recovery compared to tirzepatide monotherapy (66.1±3.1 kg vs. 63.4±3.0 kg, P<0.01).
Adding testosterone therapy may help preserve or enhance muscle mass in patients struggling with weight loss.
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Notably, while group A experienced progressive LBM loss, group B achieved significant LBM recovery (66.1±3.1 kg vs. 63.4±3.0 kg in group A, P<0.01).
Why this rating
The study design involves a controlled comparison between two treatment groups.
Source
Effects of testosterone undecanoate as add-on therapy in obese hypogonadal men that are late responders to tirzepatide: a pilot study
Giuseppe Seminara et al. · Minerva Endocrinology · 2026
other · n=10
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