Research
Hormonal
The addition of testosterone undecanoate improved insulin sensitivity and sexual health compared to tirzepatide monotherapy.
Clinicians should consider the potential benefits of testosterone therapy on metabolic and sexual health in this patient group.
StrongSupportsmedium confidence
group B showed restored testosterone levels, leading to superior improvements in insulin sensitivity (HOMA-IR: 2.9±0.6 vs. 3.8±0.7, P<0.01) and sexual health (IIEF-5: 23.2±2.1 vs. 18.0±1.5, P<0.001).
Why this rating
The study design involves a controlled comparison between two treatment groups.
Source
Effects of testosterone undecanoate as add-on therapy in obese hypogonadal men that are late responders to tirzepatide: a pilot study
Giuseppe Seminara et al. · Minerva Endocrinology · 2026
other · n=10
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