Research
Metabolic adaptation
At 2.5 years, White individuals experienced significantly greater body weight loss than Black individuals: −7.1% versus −4.9%.
Practitioners should be aware of racial differences in weight loss outcomes when prescribing GLP-1RA therapy.
StrongSupportsmedium confidence
At 2.5 years, White individuals experienced significantly greater body weight loss than Black individuals: −7.1% (95% CI −8.0%, −6.2%) versus −4.9% (95% CI −5.4%, −4.3%).
Why this rating
Based on the analysis of a large cohort from EHR data.
Source
Responses to <scp>GLP</scp> ‐ <scp>1RA</scp> in White and Black Adults With Obesity: Insights From Generalized Additive Mixed Models of <scp>EHR</scp> Data
Jordan H Mallette et al. · Obesity · 2026
DOI 10.1002/oby.70180
cohort · n=7214
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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