Research
Metabolic adaptation
Incretin-based therapies lead to reduced ectopic fat depositions in multiple organs and favourable cardiac remodelling.
Incretin-based therapies may be effective in reducing harmful fat deposits and improving heart structure in affected patients.
StrongSupportsmedium confidence
Incretin-based therapies... also leading to reduced ectopic fat depositions in multiple organs and favourable cardiac remodelling.
Why this rating
Based on emerging data indicating significant physiological changes.
Source
Reframing obesity-related HFpEF as a multiorgan syndrome: incretin-based therapies and imaging endpoints
Masliza Mahmod et al. · Heart Failure Reviews · 2026
DOI 10.1007/s10741-026-10629-z
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Incretin-based therapies such as GLP-1 RA improve symptoms, exercise capacity, congestion, and reduce heart failure events in obesity-related HFpEF.Strong
- Future clinical trials are needed to clarify the mechanisms of benefit and define the role of weight-reduction therapies in obesity-related HFpEF.Strong
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