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Energy balance
Significant reductions were observed in body weight, BMI, waist circumference, absolute fat mass, body fat percentage, and visceral fat index.
Tirzepatide effectively reduces various measures of body fat in patients with obesity.
StrongSupportsmedium confidence
Significant reductions were observed in body weight (104.6 ± 19.6 vs. 94.6 ± 20.8 kg; p < 0.0001), BMI (36.7 ± 5.3 vs. 34.9 ± 6.8 kg/m²; p = 0.02), and waist circumference (112.2 ± 11.5 vs. 105.4 ± 16.1 cm; p = 0.008). A significant decrease was also found in absolute fat mass (44.4 ± 11.1 vs. 37.1 ± 10.2 kg; p < 0.0001), body fat percentage (43.2 ± 6.2 vs. 39.0 ± 6.5 %; p < 0.0001), and visceral fat index (17.4 ± 5.1 vs. 14.4 ± 4.9; p < 0.0001).
Why this rating
Based on the analysis of real-world data from a defined patient group.
Source
Tirzepatide in real-world clinical practice: changes in body composition and muscle function in patients with obesity
Jorge Blanco Anesto et al. · Nutrición Hospitalaria · 2026
DOI 10.20960/nh.06592
cohort · n=52
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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