Research
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Hepatocyte-specific ALOXE3 expression reduces weight gain and hepatic steatosis.
Enhancing ALOXE3 expression could be a strategy for reducing obesity-related liver issues.
StrongSupportsmedium confidence
Hepatocyte-specific ALOXE3 expression reduced weight gain and hepatic steatosis in dietary and genetically obese (db/db) models.
Why this rating
The study uses robust animal models to demonstrate these effects.
Source
ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARγ
Cassandra B. Higgins et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2018
DOI 10.1101/267781
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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