Research
Molecular
PPARγ inhibition reverses ALOXE3-mediated insulin sensitization.
Inhibiting PPARγ may counteract the benefits of ALOXE3 in insulin sensitivity.
StrongSupportsmedium confidence
Strikingly, PPARγ inhibition reversed hepatic ALOXE3-mediated insulin sensitization.
Why this rating
The study provides clear evidence of the interaction through experimental results.
Source
ALOXE3 is a hepatic fasting-responsive lipoxygenase that enhances insulin sensitivity via hepatic PPARγ
Cassandra B. Higgins et al. · bioRxiv (Cold Spring Harbor Laboratory) · 2018
DOI 10.1101/267781
other
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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