Research
Hormonal
In women, an ILI-associated decrease in estradiol of 14% from baseline to year 1 mediated a decline in whole-body BMD of -1.15 mg/cm2.
Practitioners should consider the hormonal changes in postmenopausal women when implementing weight loss interventions.
StrongSupportsmedium confidence
In women, an ILI-associated decrease in estradiol of 14% from baseline to year 1 mediated a decline in whole-body BMD (-1.15 mg/cm2, 95% CI: -2.54, -0.21).
Why this rating
Based on the randomized controlled trial design.
Source
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
Jiahuan Helen He et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
DOI 10.1210/clinem/dgaf359
rct
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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