Research
Hormonal
ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss.
Weight loss interventions may lead to hormonal changes that affect bone health in older adults.
StrongSupportsmedium confidence
ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss.
Why this rating
Based on the randomized controlled trial design.
Source
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
Jiahuan Helen He et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
DOI 10.1210/clinem/dgaf359
rct
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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