Research
Hormonal
In men, an ILI-associated increase of 11% in total testosterone mediated a decline of hip BMD of -1.18 mg/cm2.
Practitioners should consider the hormonal changes in older men when implementing weight loss interventions.
StrongSupportsmedium confidence
In men, an ILI-associated increase of 11% in total testosterone mediated a decline of hip BMD (-1.18 mg/cm2, 95% CI: -2.68, -0.13).
Why this rating
Based on the randomized controlled trial design.
Source
Sex Hormones Mediate Intensive Lifestyle Intervention–Induced Bone Mineral Density Changes: Look AHEAD Sex Hormone Study
Jiahuan Helen He et al. · The Journal of Clinical Endocrinology & Metabolism · 2025
DOI 10.1210/clinem/dgaf359
rct
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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