Research
Metabolic adaptation
Insulin resistance in aging is a multisystem phenomenon reflecting declining metabolic adaptability rather than a simple glucose disorder.
Practitioners should consider insulin resistance as a complex, systemic issue in older patients, not just a glucose management problem.
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Insulin resistance in ageing is increasingly recognized as a systemic condition affecting brain metabolism, thereby contributing to cognitive decline, depression, and frailty.
Why this rating
The abstract is from a narrative review, which synthesizes existing literature.
Source
Rethinking insulin resistance in aging: A reserve-oriented clinical framework
Virginia Boccardi et al. · Ageing Research Reviews · 2026
DOI 10.1016/j.arr.2026.103180
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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