Research
Cellular
Age-related insulin resistance arises from interconnected mechanisms, including inflammaging, cellular senescence, and mitochondrial dysfunction.
Understanding these interconnected mechanisms can help in developing targeted interventions for older adults.
StrongSupportsmedium confidence
This narrative review examines the metabolic, inflammatory, and hormonal mechanisms linking ageing to insulin resistance.
Why this rating
The abstract is from a narrative review, which synthesizes existing literature.
Source
Rethinking insulin resistance in aging: A reserve-oriented clinical framework
Virginia Boccardi et al. · Ageing Research Reviews · 2026
DOI 10.1016/j.arr.2026.103180
review
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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