Research
Metabolic adaptation
Clamp-derived insulin sensitivity increased by 50% in adults with obesity and type 2 diabetes, and HOMA-IR decreased by 26% in both studies.
Improvements in insulin sensitivity are achievable through lifestyle interventions, regardless of body composition changes.
StrongSupportsmedium confidence
Clamp-derived insulin sensitivity increased by 50% (Study I), and HOMA-IR decreased by 26% in both studies.
Why this rating
Based on the structured interventions conducted.
Source
Cardiometabolic Gains Unrelated to Weight Loss–Adjusted Body Fat or Distribution Changes in Adults With and Without Diabetes
Jose E. Galgani et al. · Obesity · 2026
cohort
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