Energy balance
Aggressive weight loss via lifestyle modifications or bariatric surgery is the key intervention to reverse adverse left ventricular remodeling and improve outcomes in the obese-diabetic phenotype of heart failure with preserved ejection fraction (HFpEF).
If you have HFpEF and are obese, losing weight is the most effective way to fix the heart's stiffness. This can be done through lifestyle changes or surgery. Standard heart failure drugs often don't fix the underlying structural changes in this specific group, so focusing on reducing fat mass is critical.
aggressive weight loss via lifestyle or bariatric surgery is still key to reverse adverse left ventricular remodeling.
Why this rating
Based on a review of multiple cohort studies, RCTs, and mechanistic data linking obesity metrics to HFpEF outcomes.
Source
Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity
Aneesh Dhore-Patil et al. · Frontiers in Physiology · 2022
DOI 10.3389/fphys.2021.785879
More from this paper
- Visceral Adipose Tissue (VAT) and Epicardial Adipose Tissue (EAT) are stronger predictors of incident HFpEF and mortality than Body Mass Index (BMI) alone.Strong
- GLP-1 analogs and SGLT-2 inhibitors are promising therapeutic modalities for the obese-diabetic phenotype of HFpEF, with GLP-1 analogs showing significant reduction in epicardial adipose tissue (EAT) and body weight.Good
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