Research
Energy balance
Visceral Adipose Tissue (VAT) and Epicardial Adipose Tissue (EAT) are stronger predictors of incident HFpEF and mortality than Body Mass Index (BMI) alone.
Don't just look at your weight. For heart failure risk, where you store fat matters more. High belly fat (VAT) and heart-adjacent fat (EAT) are major risks, even if your overall weight seems okay. Imaging can help assess this risk.
StrongQualifiesVERY_HIGH confidence
Incident HFpEF correlates more closely with visceral adipose tissue (VAT) mass than body mass index (BMI)
Why this rating
Supported by multiple large cohort studies (MESA, Jackson Heart Study) with hazard ratios.
Source
Diabetes Mellitus and Heart Failure With Preserved Ejection Fraction: Role of Obesity
Aneesh Dhore-Patil et al. · Frontiers in Physiology · 2022
DOI 10.3389/fphys.2021.785879
narrative_reviewCited 20×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Aggressive weight loss via lifestyle modifications or bariatric surgery is the key intervention to reverse adverse left ventricular remodeling and improve outcomes in the obese-diabetic phenotype of heart failure with preserved ejection fraction (HFpEF).Good
- GLP-1 analogs and SGLT-2 inhibitors are promising therapeutic modalities for the obese-diabetic phenotype of HFpEF, with GLP-1 analogs showing significant reduction in epicardial adipose tissue (EAT) and body weight.Good
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