Research
Metabolic adaptation
Increased risks for coronary heart disease associated with prior cycle irregularity remained significant after adjustment for body mass index and several potential confounders.
Menstrual cycle irregularity should be evaluated in the context of other health metrics when assessing cardiovascular risk.
StrongSupportsmedium confidence
Increased risks for CHD associated with prior cycle irregularity remained significant after adjustment for body mass index and several potential confounders.
Why this rating
Based on a large prospective cohort study.
Source
Menstrual Cycle Irregularity and Risk for Future Cardiovascular Disease
Caren G. Solomon et al. · The Journal of Clinical Endocrinology & Metabolism · 2002
DOI 10.1210/jcem.87.5.8471
cohort · n=82439Cited 510×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Women reporting usually irregular or very irregular menstrual cycles had an increased risk for nonfatal or fatal coronary heart disease (CHD) with age-adjusted relative risks of 1.25 and 1.67, respectively.Strong
- There was a nonsignificant increase in overall stroke risk associated with very irregular cycles (RR, 1.30; 95% CI = 0.97-1.74).Strong
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