Research
Hormonal
Androstenedione, total plasma testosterone, albumin-bound testosterone, DHT, and SHBG decreased with increasing relative weight.
Weight management may be important for maintaining healthy hormone levels in middle-aged men.
StrongSupportsmedium confidence
Androstenedione, total plasma testosterone, albumin-bound testosterone, DHT, and SHBG decreased with increasing relative weight.
Why this rating
Based on the large sample size and cross-sectional design.
Source
The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men.
Alison E. Field et al. · The Journal of Clinical Endocrinology & Metabolism · 1994
DOI 10.1210/jcem.79.5.7962322
cross-sectional · n=1241Cited 410×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Cigarette smokers had increased serum levels of DHEA (18% higher), DHEAS (13% higher), cortisol (5% higher), androstenedione (33% higher), testosterone (9% higher), DHT (14% higher), and SHBG (8% higher) compared to nonsmokers, independent of relative weight and age.Strong
- Alcohol intake was positively associated with DHEA, cortisol, and 3-alpha-androstanediol-glucuronide.Strong
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →