Research
Molecular
Two identified polymorphisms in the leptin receptor gene result in amino acid substitutions.
These amino acid substitutions may influence leptin receptor function and obesity risk.
StrongSupportsmedium confidence
Two of these polymorphisms, Lys109Arg and Gln223Arg, are amino acid substitutions in the extracellular domain of the leptin receptor.
Why this rating
The study provides specific genetic information based on sequencing.
Source
Structure and Sequence Variation at the Human Leptin Receptor Gene in Lean and Obese Pima Indians
D B Thompson et al. · Human Molecular Genetics · 1997
DOI 10.1093/hmg/6.5.675
other · n=20Cited 145×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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