Research
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Naltrexone, bupropion, or their combination (B-N) is not associated with the incidence of major cardiovascular adverse events (MACE) compared with placebo.
Clinicians can consider that these treatments do not increase the risk of major cardiovascular events.
StrongRefutesmedium confidence
Naltrexone, bupropion, or B‐N is not associated with the incidence of MACE as compared with placebo.
Why this rating
Based on meta-analysis of 12 RCTs.
Source
Cardiovascular safety of naltrexone and bupropion therapy: Systematic review and meta‐analyses
Andrei C. Spósito et al. · Obesity Reviews · 2021
DOI 10.1111/obr.13224
Meta-analysisCited 32×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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