Research
Hormonal
GLP-1 receptor agonists (GLP-1 RAs) are prescribed for Type 2 Diabetes (ADM) and obesity (AOM), with semaglutide being the most commonly prescribed agent overall.
GLP-1 RAs like semaglutide are widely prescribed for diabetes and weight management. If you are considering this treatment, discuss insurance coverage and potential costs with your healthcare provider, as access can be limited by these factors.
ModerateSupportsMEDIUM confidence
Among first-time prescriptions for which use could be established, ADMs accounted for 86.6% and AOMs accounted for 13.4%. The most common first-time medication was semaglutide (n = 559,880).
Why this rating
Real-world observational data from a large EHR database, but not a randomized controlled trial.
Source
Monitoring Report: GLP-1 RA Prescribing Trends - September 2024 Data
Samuel Gratzl et al. · medRxiv · 2024
DOI 10.1101/2024.01.18.24301500
preprint · n=1063200Cited 18×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Dispensing rates for GLP-1 RAs are significantly lower for obesity (AOM) indications compared to diabetes (ADM) indications, with a large gap in 60-day initiation rates.Moderate
- Dispensing rates for GLP-1 RAs are lower in patients aged 65+ compared to those aged 18-64, particularly for AOM indications.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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