Research
Metabolic adaptation
Short term dietary trials are highly susceptible to bias due to physiological adaptation to major changes in nutrients.
Practitioners should be aware that results from short-term dietary trials may be influenced by the time it takes for physiological changes to occur.
StrongSupportsmedium confidence
Dietary trials, including feeding studies, are highly susceptible to bias because physiological adaptation to a major change in nutrients may take several weeks or longer.
Why this rating
The claim is based on a well-recognized issue in trial validity discussed in the abstract.
Source
Wash-in and washout effects: mitigating bias in short term dietary and other trials
David S. Ludwig et al. · BMJ · 2025
reviewCited 16×
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