Research
Cellular
Wash-in and washout effects can threaten the validity of short-term dietary trials.
Researchers should consider the timing of interventions and outcomes in dietary trials to ensure validity.
StrongSupportsmedium confidence
The effects of an intervention may, however, take time to develop and persist after discontinuation, producing wash-in and washout effects that threaten trial validity.
Why this rating
The claim is based on recognized issues in trial design discussed in the abstract.
Source
Wash-in and washout effects: mitigating bias in short term dietary and other trials
David S. Ludwig et al. · BMJ · 2025
DOI 10.1136/bmj-2024-082963
reviewCited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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