Research
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Chronic treatment of obese insulin-resistant wild-type animals with a long-acting GIPR agonist prevented rosiglitazone-induced weight gain and hyperphagia.
GIPR agonists may be beneficial in managing weight gain and overeating in insulin-resistant conditions.
StrongSupportsmedium confidence
Strikingly, chronic treatment of obese IR WT animals with a long-acting GIPR agonist prevented rosiglitazone-induced weight-gain and hyperphagia.
Why this rating
Based on the experimental design involving genetic and pharmacological approaches.
Source
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice
Ellen C Furber et al. · Diabetes · 2023
DOI 10.2337/db23-0172
otherCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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