Research
Molecular
GIPR activation influences energy balance and insulin sensitivity through mechanisms involving metabolic and thermogenic genes.
Understanding the molecular mechanisms of GIPR could inform strategies for improving insulin sensitivity.
StrongSupportsmedium confidence
The systemic insulin sensitization was accompanied by increased glucose disposal in brown adipose tissue, which was underlined by the recruitment of metabolic and thermogenic genes.
Why this rating
Based on the experimental design involving RNA sequencing.
Source
GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR Mice
Ellen C Furber et al. · Diabetes · 2023
DOI 10.2337/db23-0172
otherCited 12×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
Related findings · Molecular
- QRISK decreased markedly after weight loss from 18.9 ± 2.2% to 11.2 ± 1.6%, p < 0.0001.Strong
- Normalization of 10-year cardiovascular risk and heart age is possible after substantial dietary weight loss and remission of T2DM.Strong
- The Low-Fat Plus diet resulted in a greater reduction in total cholesterol compared to the Low-Fat diet, with changes of -0.46 mmol/L (-17.6 mg/dL) versus -0.24 mmol/L (-9.2 mg/dL) respectively (P = 0.01).Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →