Research
Mixed
Current precision nutrition tools based on Polygenic Risk Scores (PRS) have limited predictive power because they often fail to account for gene-environment interactions.
Do not rely solely on genetic testing for dietary advice. Current genetic risk scores are incomplete because they ignore your lifestyle. For accurate precision nutrition, genetic data must be combined with environmental factors like diet and activity.
GoodRefutesHIGH confidence
The development of new strategies and more efficient statistical analyses considering G × E interactions in the assessment of complex diseases are needed in the field... the inclusion of G × E interactions in the construction of PRS is expected to be the main key for improving the predictive power of precision medicine and nutrition tools.
Why this rating
Based on a systematic review of 42 GWAS, providing strong evidence for the necessity of GxE integration.
Source
Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation
Rodrigo San-Cristóbal et al. · Current Nutrition Reports · 2022
DOI 10.1007/s13668-022-00430-3
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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