Research
Mixed
FTO gene variants interact with sweet beverage consumption and alcohol intake to influence obesity and blood pressure.
If you have the FTO gene variant, be particularly mindful of your intake of sweet beverages and alcohol, as these interact with your genetics to increase obesity and blood pressure risk.
GoodSupportsHIGH confidence
FTO was the only gene associated with two different traits: obesity... and blood pressure... and interacting with four different environmental factors: physical activity... smoking habit... sweet beverage... and alcohol consumption.
Why this rating
Based on GWAS catalog data showing significant interactions.
Source
Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation
Rodrigo San-Cristóbal et al. · Current Nutrition Reports · 2022
DOI 10.1007/s13668-022-00430-3
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Physical activity attenuates the obesity-increasing genetic effects associated with the FTO locus by approximately 20-30%.Good
- Current precision nutrition tools based on Polygenic Risk Scores (PRS) have limited predictive power because they often fail to account for gene-environment interactions.Good
Related findings · Mixed
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