Mixed
Lifestyle-mediated weight loss interventions (diet and/or exercise) induce significant DNA methylation changes in blood leukocytes and adipose tissue, potentially serving as biomarkers for predicting individual response to therapy and reflecting systemic metabolic improvements.
Lifestyle changes like diet and exercise don't just change your weight; they change how your genes are expressed. This means your body's biological response to weight loss is unique and can potentially be predicted by looking at specific DNA markers before you start. Consistent lifestyle interventions can reverse obesity-associated epigenetic patterns.
In particular, intervention studies which document changes in obesity-associated epigenetic markers during weight loss can make an important contribution to this research field... intervention studies documenting changes in obesity-associated epigenetic markers during lifestyle driven weight loss, make an important contribution to a better understanding of epigenetic reprogramming in obesity.
Why this rating
Review of 19 human intervention studies, mostly genome-wide arrays, though heterogeneity in protocols exists.
Source
Implication of DNA methylation during lifestyle mediated weight loss
Samantha Aurich et al. · Frontiers in Endocrinology · 2023
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