Research
Mixed
Lifestyle interventions, particularly those involving Mediterranean diets enriched with polyphenols, can reduce DNA methylation age (epigenetic aging) in overweight and obese individuals.
Healthy lifestyle choices, including diet and exercise, can slow down your biological aging process. This means you can potentially age slower than your chronological age suggests by maintaining a healthy weight and diet.
ModerateSupportsMEDIUM confidence
lifestyle-based weight loss interventions can indeed reduce DNA methylation age (mAge)
Why this rating
Based on only two intervention studies cited in the review.
Source
Implication of DNA methylation during lifestyle mediated weight loss
Samantha Aurich et al. · Frontiers in Endocrinology · 2023
DOI 10.3389/fendo.2023.1181002
narrative_reviewCited 17×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Lifestyle-mediated weight loss interventions (diet and/or exercise) induce significant DNA methylation changes in blood leukocytes and adipose tissue, potentially serving as biomarkers for predicting individual response to therapy and reflecting systemic metabolic improvements.Good
- Baseline DNA methylation levels can serve as prognostic biomarkers to predict which individuals will successfully lose weight in response to lifestyle interventions.Good
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