Research
Hormonal
Resmetirom, a liver-targeted thyroid hormone receptor beta agonist, significantly improves both NASH resolution and fibrosis in patients with stage 2-3 fibrosis.
Resmetirom is a prescription medication for NASH with significant fibrosis that has shown the ability to improve both liver inflammation and scarring in clinical trials. It is not an over-the-counter supplement and requires medical supervision.
GoodSupportsHIGH confidence
Until now resmetirom is the only drug showing both NASH and fibrosis improvement in a phase 3 trial.
Why this rating
Based on phase 3 trial interim analysis (MAESTRO-NASH) with 955 patients.
Source
Recent updates on pharmacologic therapy in non-alcoholic fatty liver disease
Young Woon Chang et al. · Clinical and Molecular Hepatology · 2023
DOI 10.3350/cmh.2023.0356
narrative_reviewCited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Semaglutide improves NASH resolution in patients with stage 1-3 fibrosis but does not improve fibrosis or NASH resolution in patients with NASH-related cirrhosis.Good
- Obeticholic acid (OCA) reduces hepatic fibrosis without worsening NASH, but its efficacy is modest and it carries safety concerns leading to FDA rejection.Good
- Pegozafermin, an FGF21 analogue, significantly improves fibrosis and NASH resolution in patients with stage 2-3 fibrosis.Good
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