Research
Hormonal
Pegozafermin, an FGF21 analogue, significantly improves fibrosis and NASH resolution in patients with stage 2-3 fibrosis.
Pegozafermin is an experimental FGF21 analogue that has shown significant improvements in liver scarring and NASH in clinical trials, offering hope for patients with stage 2-3 fibrosis.
GoodSupportsHIGH confidence
pegozafermin, a long-acting glycopegylated recombinant FGF21 analogue, led to significant improvements in fibrosis and NASH resolution in patients with stage 2–3 fibrosis (ENLIVEN trial).
Why this rating
Based on phase 2 trial (ENLIVEN).
Source
Recent updates on pharmacologic therapy in non-alcoholic fatty liver disease
Young Woon Chang et al. · Clinical and Molecular Hepatology · 2023
DOI 10.3350/cmh.2023.0356
narrative_reviewCited 16×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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