Research
Neural
The impact of intensive lifestyle intervention (ILI) on peripheral neuropathy risk does not differ by T2D subgroups.
ILI may not be effective in reducing PN risk across different T2D subgroups.
StrongRefutesmedium confidence
The association of ILI with PN risk was null and did not differ by T2D subgroups (interaction P = 0.20).
Why this rating
Based on a large randomized controlled trial (Look AHEAD).
Source
Association of Type 2 Diabetes Subgroups With Incident Peripheral Neuropathy
Kahlia S. Simpkins et al. · Diabetes Obesity and Cardiometabolic CARE · 2026
cohort · n=2891
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