Research
Hormonal
Expression of the Ink4a/Arf locus (p16INK4a and Arf) serves as a robust biomarker of mammalian aging, with expression levels increasing significantly across multiple tissues as organisms age.
This research identifies p16INK4a and Arf as key molecular markers that increase with age in various tissues. While not yet a standard clinical test for everyone, these markers may eventually help predict disease risk and tissue regenerative capacity, offering a way to measure 'biological age' rather than just chronological age.
GoodSupportsHIGH confidence
These data suggest that expression of the Ink4a/Arf tumor suppressor locus is a robust biomarker, and possible effector, of mammalian aging.
Why this rating
Strong observational data in rodent models with consistent findings across multiple tissues and species.
Source
Ink4a/Arf expression is a biomarker of aging
Janakiraman Krishnamurthy et al. · Journal of Clinical Investigation · 2004
DOI 10.1172/jci22475
mechanism_onlyCited 1,454×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Caloric restriction (CR) attenuates the age-associated increase in Ink4a/Arf expression in specific tissues (kidney, ovary, heart, testis), correlating with reduced pathology and extended longevity.Good
- Ets-1 expression strongly correlates with p16INK4a expression with aging, suggesting Ets-1 is a principal determinant of p16INK4a expression in vivo.Good
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