Research
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Caloric restriction (CR) attenuates the age-associated increase in Ink4a/Arf expression in specific tissues (kidney, ovary, heart, testis), correlating with reduced pathology and extended longevity.
Caloric restriction can reduce the expression of aging-related genes like p16INK4a in certain organs (kidney, heart, etc.), which is linked to reduced disease. This suggests that managing calorie intake may help slow biological aging in specific tissues, although the effect is not uniform across all organs.
GoodSupportsHIGH confidence
The age-associated increase in expression of p16INK4a and Arf is attenuated in the kidney, ovary, and heart by caloric restriction, and this decrease correlates with diminished expression of an in vivo marker of senescence, as well as decreased pathology of those organs.
Why this rating
Consistent findings in rodent models showing correlation between CR, reduced biomarker expression, and reduced pathology.
Source
Ink4a/Arf expression is a biomarker of aging
Janakiraman Krishnamurthy et al. · Journal of Clinical Investigation · 2004
DOI 10.1172/jci22475
mechanism_onlyCited 1,454×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Expression of the Ink4a/Arf locus (p16INK4a and Arf) serves as a robust biomarker of mammalian aging, with expression levels increasing significantly across multiple tissues as organisms age.Good
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