Research
Hormonal
Ets-1 expression strongly correlates with p16INK4a expression with aging, suggesting Ets-1 is a principal determinant of p16INK4a expression in vivo.
The transcription factor Ets-1 is strongly linked to the increase of p16INK4a during aging. This suggests that stress signals activating Ets-1 may drive the expression of aging-related genes in tissues.
GoodSupportsHIGH confidence
Remarkably, however, a strong correlation was noted between p16INK4a and Ets-1 (r = 0.62, P < 0.001; Figure 4A)... suggests that a significant component of the in vivo variance in p16INK4a expression with aging (r2 = 0.38) results from transcriptional activation by Ets-1
Why this rating
Strong statistical correlation and mechanistic plausibility established in rodent models.
Source
Ink4a/Arf expression is a biomarker of aging
Janakiraman Krishnamurthy et al. · Journal of Clinical Investigation · 2004
DOI 10.1172/jci22475
mechanism_onlyCited 1,454×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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