Research
Hormonal
Obesity increases the risk and severity of psoriasis through a pro-inflammatory state driven by adipokines (e.g., leptin), cytokines, and gut dysbiosis.
Your body fat is not just stored energy; it actively produces inflammatory signals (like leptin) that can trigger or worsen psoriasis. Managing your weight is not just about aesthetics; it is a direct medical intervention to reduce the inflammatory drive of your skin condition.
StrongSupportsVERY_HIGH confidence
obesity is a risk factor for their onset... bidirectional relationship between obesity and psoriasis starts from a pro-inflammatory state coupled with excessive adipokines secretion such as leptin
Why this rating
Supported by extensive epidemiological, molecular, and clinical evidence reviewed in the paper.
Source
Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Gabriela Barros et al. · International Journal of Molecular Sciences · 2022
narrative_reviewCited 114×
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