Research

Micronutrients & recovery

High-fat diets, specifically those rich in palmitic acid, exacerbate psoriasis by promoting gut dysbiosis, increasing intestinal permeability ('leaky gut'), and directly activating keratinocytes and immune cells.

Dietary fats matter for psoriasis. High intake of saturated fats, specifically palmitic acid (found in many processed foods and animal fats), can worsen psoriasis by damaging the gut barrier and directly activating skin cells. Reducing these specific fats may help lower inflammation.

GoodSupportsHIGH confidence
palmitic acid facilitated IL-17-induced keratinocyte activation in vitro and that there is a strong correlation between the amount of palmitic or oleic acid in serum and the severity of skin inflammation in HFD-induced exacerbation of psoriatic dermatitis
Gabriela Barros et al. · International Journal of Molecular Sciences · 2022

Why this rating

Supported by mechanistic studies in mice and cell cultures, and clinical correlations.

Source

Exploring the Links between Obesity and Psoriasis: A Comprehensive Review

Gabriela Barros et al. · International Journal of Molecular Sciences · 2022

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