Research
Micronutrients & recovery
High-fat diets, specifically those rich in palmitic acid, exacerbate psoriasis by promoting gut dysbiosis, increasing intestinal permeability ('leaky gut'), and directly activating keratinocytes and immune cells.
Dietary fats matter for psoriasis. High intake of saturated fats, specifically palmitic acid (found in many processed foods and animal fats), can worsen psoriasis by damaging the gut barrier and directly activating skin cells. Reducing these specific fats may help lower inflammation.
GoodSupportsHIGH confidence
palmitic acid facilitated IL-17-induced keratinocyte activation in vitro and that there is a strong correlation between the amount of palmitic or oleic acid in serum and the severity of skin inflammation in HFD-induced exacerbation of psoriatic dermatitis
Why this rating
Supported by mechanistic studies in mice and cell cultures, and clinical correlations.
Source
Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Gabriela Barros et al. · International Journal of Molecular Sciences · 2022
DOI 10.3390/ijms23147499
narrative_reviewCited 114×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Obesity increases the risk and severity of psoriasis through a pro-inflammatory state driven by adipokines (e.g., leptin), cytokines, and gut dysbiosis.Strong
- Weight loss through caloric restriction and dietary modification significantly reduces psoriasis severity (PASI score) and systemic inflammation in obese patients.Good
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