Energy balance
Weight loss through caloric restriction and dietary modification significantly reduces psoriasis severity (PASI score) and systemic inflammation in obese patients.
If you have psoriasis and are overweight, losing weight is one of the most effective non-pharmacological interventions available. Studies show that losing about 12% of your body weight through structured dietary programs (like very low-calorie ketogenic diets followed by balanced diets) can significantly reduce the severity of your psoriasis symptoms, often achieving a 50-75% improvement in skin clearance. This works by reducing systemic inflammation driven by excess fat tissue.
clinical manifestations such as psoriatic flares improve with weight reduction and physical activity... a 12% weight reduction in patients with obesity resulted in a PASI decrease of 50–75%, with significant improvement in psoriasis severity and quality of life index score
Why this rating
Supported by a meta-analysis of RCTs and specific open-label clinical trials showing significant PASI improvements.
Source
Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Gabriela Barros et al. · International Journal of Molecular Sciences · 2022
DOI 10.3390/ijms23147499
More from this paper
- Obesity increases the risk and severity of psoriasis through a pro-inflammatory state driven by adipokines (e.g., leptin), cytokines, and gut dysbiosis.Strong
- High-fat diets, specifically those rich in palmitic acid, exacerbate psoriasis by promoting gut dysbiosis, increasing intestinal permeability ('leaky gut'), and directly activating keratinocytes and immune cells.Good
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