Research
Hormonal
Peripheral administration of Pancreatic Polypeptide (PP) induces satiety and reduces energy intake in both rodents and healthy humans, primarily through activation of hypothalamic Y4 receptors.
Peripheral PP administration reduces food intake, but its short half-life limits its current therapeutic use. Future therapies may utilize long-acting, enzyme-resistant PP analogues.
ModerateSupportsMEDIUM confidence
peripheral administration of PP results in reduced energy intake in rodents [61] and healthy humans [7].
Why this rating
The paper is a review summarizing various studies, including human trials, but notes limited direct evidence for sustained weight loss.
Source
Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes
Wuyun Zhu et al. · Peptides · 2022
DOI 10.1016/j.peptides.2022.170923
narrative_reviewCited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Sustained activation of pancreatic Y1 receptors improves beta-cell turnover, preserves beta-cell identity, and enhances insulin secretory responsiveness in rodent models of diabetes.Moderate
- PP protects against beta-cell apoptosis and may improve insulin sensitivity by enhancing the availability of insulin receptors.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →