Research
Hormonal
Sustained activation of pancreatic Y1 receptors improves beta-cell turnover, preserves beta-cell identity, and enhances insulin secretory responsiveness in rodent models of diabetes.
Sustained Y1 receptor activation improves beta-cell function in rodents, suggesting potential anti-diabetic benefits.
ModerateSupportsMEDIUM confidence
prolonged activation of pancreatic Y1 receptors leads to established benefits on beta-cell turnover, preservation of beta-cell identity and improved insulin secretory responsiveness.
Why this rating
Based on rodent models, with translation to humans still required.
Source
Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes
Wuyun Zhu et al. · Peptides · 2022
DOI 10.1016/j.peptides.2022.170923
narrative_reviewCited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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