Research
Hormonal
PP protects against beta-cell apoptosis and may improve insulin sensitivity by enhancing the availability of insulin receptors.
PP may protect beta-cells and improve insulin sensitivity, suggesting potential anti-diabetic benefits.
ModerateSupportsMEDIUM confidence
native PP has been shown to protect against beta-cell apoptosis [44]... PP has been reported to improve insulin sensitivity through enhancing the availability of haptic insulin receptors [77]
Why this rating
Based on rodent studies, with human translation required.
Source
Pancreatic polypeptide revisited: Potential therapeutic effects in obesity-diabetes
Wuyun Zhu et al. · Peptides · 2022
DOI 10.1016/j.peptides.2022.170923
narrative_reviewCited 41×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Peripheral administration of Pancreatic Polypeptide (PP) induces satiety and reduces energy intake in both rodents and healthy humans, primarily through activation of hypothalamic Y4 receptors.Moderate
- Sustained activation of pancreatic Y1 receptors improves beta-cell turnover, preserves beta-cell identity, and enhances insulin secretory responsiveness in rodent models of diabetes.Moderate
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