Mixed
Persistent metabolic syndrome (MetS) and the development of MetS over time are associated with a significantly increased risk of incident atrial fibrillation (AF), with risk increasing proportionally to the number of MetS components.
Maintaining metabolic health is critical for preventing atrial fibrillation. If you have metabolic syndrome (high blood pressure, high blood sugar, high triglycerides, low HDL, or abdominal obesity), your risk of AF is significantly higher. Even if you improve your metabolic health later, your risk remains higher than someone who was always metabolically healthy, though it is lower than if you had kept the syndrome. The best strategy is to prevent MetS from developing in the first place, especially if you are young or middle-aged.
After multivariable adjustment, the AF risk was higher by 31% in the patients with persistent MetS , 26% in the patients with MetS who were healthy in the second evaluation, and 16% in the healthy patients newly diagnosed with MetS in the second evaluation compared with the persistently healthy individuals.
Why this rating
Large-scale nationwide observational cohort (n=7.5M) with long follow-up (mean 7.9 years), though observational design limits causal inference.
Source
Association Between Change in Metabolic Syndrome Status and Risk of Incident Atrial Fibrillation: A Nationwide Population‐Based Study
Seo‐Young Lee et al. · Journal of the American Heart Association · 2021
DOI 10.1161/jaha.121.020901
Related findings · Mixed
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