Mixed
The Core Obesity Model (COM) accurately predicts obesity-related event rates for type 2 diabetes, cardiovascular disease, and obstructive sleep apnea when validated against studies used for its development.
For decision-makers using the Core Obesity Model, the dependent validation results provide high confidence that the model accurately predicts the rates of T2D, CVD, and OSA for populations similar to those used in its development. This supports the use of the model for cost-effectiveness analyses in these specific contexts.
The concordance observed in the external dependent validation suggests that the COM accurately predicts obesity-related event rates observed in the studies used to develop the model.
Why this rating
High-quality validation using multiple large datasets and established statistical methods (R2, slope analysis).
Source
External Validation of the Core Obesity Model to Assess the Cost-Effectiveness of Weight Management Interventions
Sarila Hali Kloster Lopes et al. · PharmacoEconomics · 2020
DOI 10.1007/s40273-020-00941-3
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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