Mixed
The Core Obesity Model tends to underestimate the incidence of cardiovascular disease, mortality, and type 2 diabetes when validated against independent studies not used in its development.
When using the Core Obesity Model for independent validation, be aware that it tends to underestimate the rates of CVD, mortality, and T2D. This underestimation is particularly pronounced for mortality and stroke. However, the model still shows good linear correlation, and the underestimation may not significantly impact incremental cost-effectiveness ratios if it affects both intervention and comparator arms similarly.
The independent validation revealed a degree of underestimation in predictions of cardiovascular (CV) disease and mortality, and type 2 diabetes.
Why this rating
Based on independent validation using multiple RCTs and observational studies.
Source
External Validation of the Core Obesity Model to Assess the Cost-Effectiveness of Weight Management Interventions
Sarila Hali Kloster Lopes et al. · PharmacoEconomics · 2020
DOI 10.1007/s40273-020-00941-3
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
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