Energy balance
The molecular clock component BMAL1 is required for satellite cell proliferation and the metabolic transition from oxidative to glycolytic energy sources during early muscle regeneration.
BMAL1 acts as a metabolic switch for muscle stem cells. When muscle is damaged, these cells must switch from resting energy (oxidative) to building energy (glycolytic) to multiply. BMAL1 regulates this switch. Disrupting your circadian rhythm (e.g., chronic shift work) might impair this metabolic flexibility, potentially slowing down the initial proliferation phase of muscle repair.
As SCs from SC-BMAL1 KO mice cannot transition into glycolysis, it is likely that BMAL1 circadian input is required for SC transitions between energetic states and thus, appropriate, and successive expression of MRFs supporting proliferative demands.
Why this rating
Derived from BMAL1-null and SC-specific BMAL1 KO mouse models; mechanism is well-established in mice but less clear in humans.
Source
Molecular clocks, satellite cells, and skeletal muscle regeneration
Ryan E. Kahn et al. · American Journal of Physiology-Cell Physiology · 2023
DOI 10.1152/ajpcell.00073.2023
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