Mixed
The term 'non-responder' should be restricted to specific organs or physiological functions rather than applied to the whole individual, as exercise-induced adaptation is systemic and a lack of response in one area (e.g., VO2max) does not preclude adaptation in others (e.g., immune function or muscle metabolism).
If you aren't seeing improvements in your main goal (like running faster or lifting heavier), don't assume exercise isn't working for you. Your body is likely adapting in other ways, such as improved immune function, better blood flow, or metabolic health. The 'right' exercise for you might be different from what you are currently doing, so consider adjusting the type or intensity of your training rather than stopping.
Lack of adaptation or moderate level of adaptation in one organ or one physiological function would not mean that other organs or functions would not benefit from exercise training. ... Hence, the term of non-responders should be used with caution and just referred to a given organ, cell type, molecular signaling, or function.
Why this rating
Based on a review of multiple studies and animal models, though it is a theoretical framework rather than a single clinical trial.
Source
Issues on Trainability
Zsolt Radák et al. · Frontiers in Physiology · 2022
DOI 10.3389/fphys.2021.790196
More from this paper
- High-Intensity Interval Training (HIIT) or Sprint Interval Training (SIT) is more effective than moderate-intensity continuous training (MICT) for inducing specific metabolic adaptations (such as PGC1-α, NRF1, TFAM) in individuals who do not respond to moderate-intensity training.Good
- Antioxidant supplementation (specifically Vitamin C and E) can attenuate exercise-induced adaptations, such as mitochondrial biogenesis and improvements in VO2max, by interfering with reactive oxygen species (ROS) signaling pathways.Good
Related findings · Mixed
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This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →