Research
Mixed
A 4 cm increase in abdominal circumference in men under 50 is associated with a 1.48 hazard ratio for developing MACCE, independent of systolic blood pressure changes.
For men under 50, gaining 4 cm around the waist over a few years nearly doubles the relative risk of a major cardiac or cerebrovascular event. Maintaining waist circumference is a key preventive strategy.
GoodSupportsHIGH confidence
Compared with Visit 1, if the abdominal circumference increased by 4 cm at Visit 3, the hazard ratio for developing MACCE was approximately 1.5 (hazard ratio 1.48; 95% CI, 1.18-1.86).
Why this rating
Derived from the same robust observational cohort with landmark analysis.
Source
Effects of Longitudinal Changes in Lifestyle-Related Risk Factors on the Incidence of Major Adverse Cardiac and Cerebrovascular Disease in Young Adults
Mitsuko Nakata et al. · International Heart Journal · 2022
DOI 10.1536/ihj.22-317
cohort · n=12528Cited 1×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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