Research
Mixed
Acute exercise (both HIIT and MICT) results in more phosphosite down-regulation than up-regulation, suggesting that acute exercise involves the inhibition of kinase activity and/or activation of phosphatases.
Exercise doesn't just turn things on; it also turns things off. This balance is crucial for adaptation. Don't assume more activation is always better; regulation (inhibition) is part of the process.
GoodQualifiesHIGH confidence
More phosphosites were down- versus up-regulated in response to each exercise intensity and timepoint, suggesting acute exercise-regulated inhibition of kinase activity and/or activation of phosphatases.
Why this rating
Based on the same high-quality phosphoproteomic data as N1.
Source
Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants
Nolan J. Hoffman et al. · Sports Medicine · 2025
DOI 10.1007/s40279-025-02217-2
crossover · n=10Cited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High-intensity interval training (HIIT) engages a unique subset of skeletal muscle signaling networks compared to work-matched moderate-intensity continuous training (MICT), specifically involving kinases and pathways associated with plasma lactate levels.Good
- High-intensity interval training (HIIT) elicits higher plasma lactate concentrations than work-matched moderate-intensity continuous training (MICT) during the exercise bout.Good
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