Research
Energy balance
High-intensity interval training (HIIT) elicits higher plasma lactate concentrations than work-matched moderate-intensity continuous training (MICT) during the exercise bout.
If you do HIIT, you will produce more lactate than if you did moderate continuous training of the same work. This is expected and part of what drives the unique adaptations.
GoodSupportsHIGH confidence
Plasma lactate concentrations throughout HIIT were higher than MICT (P < 0.05)
Why this rating
Statistically significant difference reported in the crossover trial.
Source
Phosphoproteomics Uncovers Exercise Intensity-Specific Skeletal Muscle Signaling Networks Underlying High-Intensity Interval Training in Healthy Male Participants
Nolan J. Hoffman et al. · Sports Medicine · 2025
DOI 10.1007/s40279-025-02217-2
crossover · n=10Cited 11×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- High-intensity interval training (HIIT) engages a unique subset of skeletal muscle signaling networks compared to work-matched moderate-intensity continuous training (MICT), specifically involving kinases and pathways associated with plasma lactate levels.Good
- Acute exercise (both HIIT and MICT) results in more phosphosite down-regulation than up-regulation, suggesting that acute exercise involves the inhibition of kinase activity and/or activation of phosphatases.Good
Related findings · Energy balance
- Achieving a total body weight loss of 10-15% (or >10-15 kg) through Total Diet Replacement (TDR) induces remission of Type 2 Diabetes in individuals with short-duration disease.Strong
- Bariatric surgery is superior to medical management alone for inducing significant long-term weight loss, remission of type 2 diabetes, and reduction in mortality for patients with BMI ≥ 40 or ≥ 35 with comorbidities.Strong
- Achieving type 2 diabetes remission requires significant weight loss (≥15 kg) via major caloric restriction, independent of macronutrient composition.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →