Micronutrients & recovery
Higher predicted plasma 25-hydroxy-vitamin D levels are associated with significantly reduced total cancer incidence and mortality, with the strongest protective effects observed for digestive-system cancers.
Maintain healthy vitamin D levels, potentially through sun exposure and diet, as higher levels are linked to lower cancer risk in men. The study suggests that achieving a 25 nmol/L increase in blood levels might require at least 1500 IU/day of supplementation, though individual needs vary based on skin pigmentation, BMI, and geography.
From multivariable models, an increment of 25 nmol/L in predicted 25(OH)D level was associated with a 17% reduction in total cancer incidence (multivariable relative risk [RR] = 0.83, 95% confidence interval [CI] = 0.74 to 0.92), a 29% reduction in total cancer mortality (RR = 0.71, 95% CI = 0.60 to 0.83), and a 45% reduction in digestive-system cancer mortality (RR = 0.55, 95% CI = 0.41 to 0.74).
Why this rating
Large prospective cohort (47,800 men) with long follow-up and rigorous multivariable adjustment, but observational design limits causal inference.
Source
Prospective Study of Predictors of Vitamin D Status and Cancer Incidence and Mortality in Men
Edward L. Giovannucci et al. · JNCI Journal of the National Cancer Institute · 2006
DOI 10.1093/jnci/djj101
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