Research
Micronutrients & recovery
Omega-3 polyunsaturated fatty acid (EPA+DHA) supplementation does not reduce the risk of cardiovascular events or mortality in patients with diabetes mellitus or prediabetes.
If you have diabetes or prediabetes, taking fish oil supplements will not protect your heart or prevent heart attacks. Do not take them for this purpose. Focus on proven diabetes management strategies instead.
GoodRefutesHIGH confidence
Taken together, available data do not support omega-3 PUFA supplementation among patients with diabetes mellitus or prediabetes to prevent cardiovascular events. Overall, the current evidence from RCTs suggests no benefit of omega-3 PUFA supplementation among patients with or at risk for diabetes mellitus to prevent CVD (Treatment is not indicated: Class III: No Benefit Recommendation).
Why this rating
Based on large RCTs (ORIGIN trial, n=12,536) and meta-analyses of subgroup findings.
Source
Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease
David S. Siscovick et al. · Circulation · 2017
DOI 10.1161/cir.0000000000000482
clinical_guidelineCited 621×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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